The present results for the first time demonstrate that vaspin inhibits MGO-induced EC apoptosis by preventing caspase-3 activation via the inhibition of NOX-derived ROS generation.
A dog showed urinary incontinence sign, anorexia, vomiting, and high fever. Radiographic revealed left kidney calculus, and enlargement kidney. A calculus with urinary bladder thickening was observed. Ultrasonography showed acoustic shadowing from the stone both left kidney and urinary bladder, and large anechoic area in a kidney. Abdominal surgery revealed pus from renal abscess rupture with fibrosis adhesion between renal and surrounding tissue. Cystotomy and nephrectomy were performed removing calculi. Peritoneal lavage with ceftriaxone was performed before suturing close of abdomen. Postoperative care with intraperitoneal injection of ceftriaxone was performed 5 day consecutively. A dog could be eaten and walk 2days after operation. No septic peritonitis sign appeared after 30 days of operation. Proteus mirabilis was cultured from the kidney swab. The histological examination of kidney showed severe necrotic pyogranulomatous pyelonephritis. The excellent results revealed ceftriaxone by peritoneal lavage and intraperitoneal injection with nephrectomy surgery could be treated Proteus mirabilis septic peritonitis from renal abscess rupture.
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