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Figure 1 A-B: (A) Retrieved titanium-alloy femoral porous-coated surface replacement bisected to show the replacement of bone by an invasive granulamalike tissue. This component failed after 50 months in an active 62-year-old man. (B) Histology of the tissue within the femoral head shows sheets of macrophages and giant cells, many with fine, intracellular metallic or UHMWPE debris. Lymphocytes are rarely seen in theses tissues. (Stain, toloidine blue; original magnification, X60.)

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