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A white-light source operated polymer-based micromachined Fabry-Perot biochemical sensor is reported. As a refractive-index sensitive optical sensor, its transducing signal varies upon the changes of the effective refractive index in the Fabry-Perot cavity. This sensor is fabricated from PDMS and glass. More specifically, this sensor is a micromachined Fabry-Perot interferometer (microFPI) and is fabricated by bonding a glass substrate and the soft-lithographically patterned PDMS. Several biochemicals have been detected with the microFPI biochemical sensors. Measurements show that rabbit IgG at a concentration of as low as 5 to 50 ng/ml can be detected even without any performance optimization of the devices.

This paper reports a new class of biosensors based on composite nanomaterial thin film. The composite nanomaterial film is synthesized using a simple vacuum filtration method. Using composite nanomaterial film, we can not only simplify the positioning and integration fabrication process of nanoscale materials into a functional device, but also enhance the sensing surface area significantly, which might open an opportunity to fabricate devices for ultrasensitive biosensing in a cost-effective way. Systematic measurements find that the composite film, containing carbon nanotubes (CNTs) and SnO 2 nanoparticles, shows the similar field effect as that of single CNTs or nanowires (NWs) and its resistance changes upon binding to biomolecules during a bioassay process.I.

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