Aralık 2019' dan beri görülmeye başlayan COVİD-19 salgını tüm dünyayı etkilemiştir. 11 Mart 2020' de ülkemizde ilk vaka tespit edilmiştir. Yoğun infektivitesi olan bu virüs karşısında sağlık çalışanları en yüksek risk altındaki meslek grubudur. Çin' de salgın sırasında ilk üç ay içinde 1500'ün üzerinde sağlık çalışanı enfekte olmuştur. Bu yüksek maruziyet riski nedeniyle gözlük, bone, tulum, maske gibi kişisel koruyucu donanımların yerinde ve uygun kullanımı önem kazanmaktadır. Bu derlemede sağlık çalışanlarının COVİD-19 salgınında iş sağlığı ve güvenliği ilkeleri kullanılarak mesleki bulaş risklerini azaltma yolları ve yöntemleri irdelenmiştir.

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Summary Background Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. Methods 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. Results When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). Conclusions In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure.

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