Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instrument in both rats and rabbits. Each group consists of 10 animals (6 rats + 4 rabbits). Group 1 received test drug 0.1% novel folic acid gel formulated by us, Group 2 was positive control and received standard local drug 0.1% Kenacort triamcinolone oromucosal paste and Group 3 served as a negative control group where no treatment was given. Results: No untoward reaction was observed on the irritancy test. Kruskal–Wallis test applied for comparison of results. After 1 week of post-ulcer induction, there was a marked improvement in healing of oral ulcers in both Group 1 and Group 2, but more statistically significant healing was seen in Group 1 (folic acid gel). Both Groups 1 and 2 showed steady improvement in the healing of oral ulcers as compared to their pre-treated values and again were more marked in Group 1. Conclusion: Local folic acid gel supplementation was safe and had shown to augment oral ulcer healing in rats and rabbit’s animal models.

not available Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 256-257

Migraine is a common debilitating headache presenting with severe one-sided pulsatile and throbbing pain. It has been observed that symptoms of the migraine are commonly aggravated in summer season. Ramadan is the 9th month of the Hijri calendar, observed by Muslims all over the world as a month of fasting. Fasting in the month of Ramadan is one of the five pillars of Islam. In this paper, a concept note is prepared to look the Prophetic ways in preventing and controlling migraines during Ramadan especially during the summer seasonfrom the Islamic and scientific perspective. Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 280-283

We know that probiotics are found to be useful in various conditions like irritable bowel syndrome, opioid tolerance, indigestion, depression, anxiety, and ADHD. But still, we don’t know the proper mechanism involved in the treatment of these conditions by probiotics supplementation. In this Letter to Editor, I have written one interesting hypothesis which connects probiotics’ common mechanism of action to all these diseases.International Journal of Human and Health Sciences Vol. 05 No. 03 July’21 Page: 375-376