A 70-year-old female presented with a long history of HIV and 5 years of disturbing delusions of infestation that impaired her daily functioning. The delusions resolved with haloperidol but were followed by depressive symptoms. The case presents the complexity of managing neuropsychiatric manifestations of HIV/ AIDS with comorbidities in old age.

A 70-year-old female presented with a long history of HIV and five years of disturbing delusions of infestation that impaired her functioning. The delusion resolved with haloperidol but was followed by depressive symptoms. The case presents the complexity of managing neuropsychiatric manifestations of elderly patient with HIV/AIDS and medical comorbidities