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ACKNOWLEDGEMENTS. We thank G. Frey for M. kandleri cells, L. Liu for antibody aga inst human topoisomerase I, H. Nash for). Int protein , Y. C. Tse-Dinh for E. coli topoisomerase I. J. Wang tor S. cerevisiae topoisomerase Ill and antibody against E. coif topoisomerase I, and C. Scheim er and K Eichinger for technical assistance. The work was supported in part by funds from the Leibniz Preis (K.S.) and the NSF (JAL.), and by Alexa nder von Humboldt and Alfred P. Sloan fellowships (to A.LS.).