Introduction: Magnetic Resonance Cholangiopancreatography (MRCP) is a non-invasive and important imaging modality useful for study of pancreas and biliary system using advanced rapid imaging and invention of new sequences for pancreatic and biliary ductal system. Aims and Objectives: To study role of Magnetic Resonance Cholangiopancreatography (MRCP) finding in various pancreatico-biliary pathologies. Results: Total 60 cases were studied with various pancreatico-biliary conditions. Variety of study showed that 37(62%) out of 60 cases were encountered with biliary pathologies followed by pancreatic lesion in 17(29%) cases and pancreatic-biliary lesions were present in 6 (9%) cases. Among the lesions, most common cases were of obstructive etiology in 24(40%) followed by inflammatory condition in 21(36%), congenital lesions in 7(11%), neoplastic lesions seen in 6(10%) and strictures in the 2 (3%) cases. Conclusion: According to our study, MRCP is an advanced and noninvasive diagnostic imaging of choice for the pancreatico-biliary lesions.