Publicly available seismic and well data are used to study the subsurface structure and stratigraphy of an area on the southern margin of the Central Indus Basin (CIB), Pakistan. Study area includes southern parts of the Punjab Platform and Sulaiman Foredeep tectonic units of the CIB. A regional scale East-West depth cross-section is prepared in South of hydrocarbon bearing Safed Koh Trend to Punjab Platform. It gives the structural configuration of various formations of Paleozoic-Cenozoic times. Reflectors are marked and correlated with the help of wells Drigri-01 and Bahawalpur East-01, located on seismic lines 914-RPR-03 and 916-YZM-05 respectively. These reflectors/formations are correlated with respect to ages to avoid the confusions as there are many truncations in the area. Average velocities are used for the depth computation. Depth cross-section (AB) shows that Punjab Monocline is a stable area with a shallow basement. In Punjab Platform all the formations dip gently to the West. Then they attain steep dips in the Sulaiman Foredeep/Depression area. Depth cross-section along the Drigri anticline which lies in the SE of Sakhi Sarwar anticline reveals that it is extended E-W over 17 km approx. and the reverse faults are present on both flanks of a fold, due to that a pop up structure is formed. It's a low amplitude fold, as it marks the southern end of Safed Koh Trend (first line of folding of the folded flank of Sub-Sulaiman Fore Deep). Subsurface structural variations at Bahawalpur show a buried high of Jurassic-S. Asim et al. 1232 Permian age. A sedimentary cover is 9 km thick in West and 3 m thick in East. Basement is uplifted at Bahawalpur High.