Phenylephrine is a medication mainly applied as a decongestant to relieve hemorrhoids, increase blood pressure, and dilate the pupil. It is the first-line choice for prevention and treatment of hypotension during spinal anesthesia for cesarean section. However, many methods were used for the determination of this drug and its properties. This paper proposes a method that uses N, N dimethyl-p-phenylenediamine dihydrochloride as a new chromogenic reagent (NNDPH). This method is based on the oxidative coupling reaction of phenylephrine with N, N dimethyl-p-phenylenediamine dihydrochloride with ferric chloride in basic media to form green-blue soluble dye product. The outcomes demonstrate that the maximum absorption is at 680 nm, molar absorptivity of 5.54 × 103 mol-1.cm-1, and Sandell’s sensitivity of 0.038 μg.cm-2. The concentration range of 4 to 22 μg.mL-1 of the product is conformable to Beer’s law. Furthermore, it is applied successfully for estimating the drug properties on a simple condition or pharmaceutical preparations.

An easy and simple spectrophotometric method was described for estimating chlorpromazine Hydrochloride drug in aqueous solution. Where The method was adopted on oxidative coupling reaction of the drug with p-nitro aniline in the presence of ceric(IV) ammonium nitrate and hydrochloric acid solution an orange-brown product dye was obtainded with maximum absorption at 525 nm. with moler absorptivity of 9.24×10 3 l. mol-1. cm-1 and sandell's sensitivity of 0.0385 µg.cm-2 Beer's law is obeyed over the concentration range of (12-46) µg.ml-1. The method was applied successfully for the estimating the drug it's on pure condition or in pharmaceutical preparations (Largactil drug).

An evaluation of pollution level has been done for drinking water which is used in Kirkuk city by heavy metals ( As,Cd,Cu,Fe,Mn,Ni,Zn,Cr,Pb) samples were collected during wet and dry of 2016-2017 from Kirkuk unified water supplied project (WTP) which is supply the city with drinking water, as well as from water of tanks type (GST2), and also from (tap water) (Zone3). The results showed the concentration of the (As,Cd,Cu,Fe,Mn,Ni,Zn,Cr,Pb)inppbfor (WTP)are (0.5,0.6,6.45,38,4.6,2.5,6537,0.58,1.4) (0.6,0.8,6.76,46,5.5,3.5,6675,1,2.4) for (GST) (0.5,0.63,6.46,52.3,4.4,3.6,6550,0.6,2.5) (0.60,0.7,6.78,63.7,6.7,3.7,6680,1.1,2.6) and for tap water are (0.53,0.65,7.00,60.2,4.4,3.65,7200,0.8,2.7) (0.60, 0.71, 7.10, 67.6, 6.8,3.75,7320,0.9,2.75) for two seasons respectively the concentrations are within the allowed limits by WHO just Zn is exceed the allowed limits . the level of health risks were also assessed by using a number of indices (HQ)ing, (HQ) derm, (HI), (CR) ing (CR) derm for adult and children and for two seasons . (HI) value for Zn show health risks this high value of (HI) for Zn make water undrinkable.

A simple , rapid and sensitive spectrophotometric method for the determination of microgram amounts of chlorpromazine Hydrochloride drug in aqueous solution is described. The method is based on the oxidative coupling reaction between chlorpromazine hydrochloride and N,Ndimethyl-p-phenylenediaminedihydrochloride (DMPD) in the presence of sodium periodate and hydrochloric acid to form an intense red colored product with maximum absorption at 525 nm. Beer's law is obeyed over the concentration range of(4-34) µg.ml-1 with moler absorptivity of 9.239x10 3 l. mol-1. Cm-1 and sandell's sensitivity of 0.038 µg.cm-2. The method does not resort to temperature control or to solvent extraction. The optimum conditions for all color development are described and the proposed method has been successfully applied for the determination of chlorpromazine Hydrochloride in bulk drug and pharmaceutical preparations (Largactil drug).