Erythema nodosum leprosum (ENL) is a common complication of lepromatous leprosy. Some patients unresponsive to conventional, first-line therapeutics develop recurrent, recalcitrant ENL. Here, we report a case of severe refractory ENL that was successfully treated with Etanercept. Biologics may be considered as therapeutic alternatives in management of severe, recalcitrant ENL.

Seborrheic dermatitis is a common inflammatory condition mainly affecting scalp, face and other seborrheic sites, characterized by a chronic relapsing course. The mainstay of treatment includes topical therapy comprising antifungals (ketoconazole, ciclopirox olamine) and anti-inflammatory agents along with providing symptomatic relief from itching. Oral antifungals and retinoids are indicated only in the severe, recalcitrant cases. The objective of this review is to discuss various topical antifungals available for use in seborrheic dermatitis of scalp, face and flexural areas, discuss their efficacy and safety profiles from relevant studies available in the literature along with upcoming novel delivery methods to enhance the efficacy of these drugs.

No abstract