Background: Origin recognition complex (ORC) binds to the replication origin for initiation of eukaryotic chromosome replication. Results: Phosphorylation of human ORC2 in the S phase dissociates ORC from chromatin and replication origins. Conclusion: Phosphorylation of ORC2 dissociates ORC from DNA and inhibits binding of ORC to newly replicated DNA. Significance: Phosphorylation of ORC2 controls chromatin binding of ORC.

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