Introduction and Aim: Due to the Coronavirus outbreaks, the SARS-CoV-2, also known as COVID-19, has claimed several lives around the world, with the majority of them being elderly, suffering from underlying chronic illnesses, or living in vulnerable conditions. This study aimed to find the immunological factors CD-79, CD-4, IL-2, and TNF-B in COVID-19 patients utilizing nucleocapsid-(N), a protein structure that interacts with genomic RNA to create complexes.   Materials and Methods: SARS-COV-2 infection was detected using RT-PCR. The serum levels of IL-2 and TNF-B, as well as the concentrations of CD4 and CD79, were measured. This study included 100 COVID-19 patients.   Results: The results showed that the serum concentration of TNF-beta and IL-2 in COVID19 patients was significantly higher than that in the general population (with acute and moderate illness) when compared to normal control groups (p 0.05). COVID-19 patients reported higher levels of CD79 as well as CD4 expression than healthy control groups in a study of activated markers.   Conclusion: Infection with SARS-COV-2 has a high impact on various immunological and inflammatory markers in patients.