It is been mentioned that Pseudomonas aeruginosa, a ubiquitous, gram negative, can infect patients with Cystic fibrosis. Treatment of infections can often be difficult due to its ability to produce biofilm. It has been revealed that biofilms are enclosing architecture that would consist of planktonic cells to survive in harsh environments. Biofilm is usually comprised of Pel, Psl, and Alginate, and many others to make a scaffold that bacteria can attach and start making microcolonies. The formation of the biofilm and Alginate layer is shown to be controlled by intricate cell-to-cell communication known as quorum sensing (QS). Finally, in this report, we have taken the basic principles of what is P.aerogenosa, and how it is related to the cystic fibrosis disease. Also, we have illustrated the formation of biofilms and the regulation of biofilms to the quorum sensing LasR/LasI and RhlR/RhlI systems.