BACKGROUND:Melasma is a commonly acquired hyperpigmentation which present as irregular, light to dark brown macules on sun exposed skin due to various etiological factors including hormonal imbalance. AIM: To assist the level of various hormones and study the clinical and hormonal correlation in patients of melasma. METHODS: 50 female patients of melasma between age group 18-50 with equal number of age matched females with no signs of melasma, hirsutism and any other endocrinal abnormality, were enrolled. They were examined by woods' lamp to see the type of melasma whether epidermal, dermal or mixed. 10 ml of venous blood sample was drawn after overnight fasting on 3 rd -5 th day of the menstrual cycle in mid follicular phase for the assessment of LH, FSH, Prolactin, Estradiol and Progesterone by chemiluminescence method. RESULT: Out of 50 patients, 8 patients had deranged level of LH, 7 patients had deranged level of FSH, 14 patients had deranged prolactein, 18 patients had deranged estradiol and 6 patients had deranged level of progesterone. 70% patients were married and belong to age group of 31-40 years. 18 % patients has onset of melasma during pregnancy while 52% patients after the delivery. CONCLUSIONS: LH, estradiol and progesterone are found to be contributory factors in development of melasma.

Introduction:Dermatophytosis is a superficial fungal infection of keratinized tissue. The infection is known as tinea. Various oral and topical antifungal agents used in clinicalpractice.Objective: Comparative study between oral terbinafine and griseofulvin in dermatophytosis infection in children between 5 to 15 years Methods: Patients of both gender and age between 5 to 15 years diagnosed as dermatophytic infection were enrolled for the study. Atotal of 100 patientswere divided into two groups. One group was treated with oral terbinafine and other withoral griseofulvin for 4 weeks. In addition a placebo cream/ lotion was applied locally. Limitation: Large studies are required for more confirmation. Conclusion: Oral terbinafine produced 88 percent cure while cure with griseofulvin was 72 percent .Clinical response to oral terbinafine was 16percentbetter.No significant adverse effects were noticed in either groups, except in some cases mild gastrointestinal disturbance.

Lichen sclerosus et atrophicus (LSA) is a disease of unknown etiology. Although the anal and genital regions are predominantly affected, 2.5% of patients only present with extra genital lesions-particularly of the trunk, neck, and upper limbs. The wrists, palm plantar regions, nipples, and face are less commonly involved. We report here a case of rare presentation of extra genital LSA associated with genital LSA.

A case of large plaque parapsoriasis with extensive skin lesions is presented for its unusual clinical features. The controversial issue of its nosological position is discussed as it has a considerable impact on the management of such cases.