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The present work demonstrates the use of novel properties of ceria magnetic nanoparticles (CeO 2-Fe 3 O 4 NPs) as oxidase mimetics to detect catechol. The CeO 2-Fe 3 O 4 NPs was prepared by simple co-precipitation method. The prepared nanoparticles were confirmed by different techniques such as FTIR, XRD, SEM-EDS, and XPS. CeO 2-Fe 3 O 4 NPs exhibits similar activity as tyrosinase enzyme to catalyse the oxidation of colorless catechol to colored quinone complex, which provides colorimetric detection of catechol. Characterization techniques show that the oxidase activity of the CeO 2-Fe 3 O 4 NPs initiates due to Ce 4+ /Ce 3+ and quinone complex formation by catechol ligand. In addition, CeO 2-Fe 3 O 4 NPs can be easily separated from the reaction solution by using a magnet and reused for the next cycle.