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In this article, we study the synthesis of 1‐substituted indazole‐3‐carboxylic acids from 2‐halobenzoic acids.

A new series of 1H-pyridin-4-yl-indazole-3-carboxylic acid and its derivatives were synthesized from indazole-3-carboxylic acid methyl ester and 2-cyano-4-chloropyridine. All the new compounds have been characterized by spectral data and subsequently evaluated for their anti-inflammatory and analgesic activity.

4‐Nitro‐pyridine‐N‐oxides are reacted with ethylchloroformate and trimethylsilyl cyanide to give 4‐chloro‐2‐cyanopyridine. J. Heterocyclic Chem., (2011).

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