The present research reflected towards exploring the plausible role(s) of extracts of Dolichos biflorus (seed), Cichorium intybus (root), Pterocarpus marsupium (bark), and Crataeva nurvala (bark) formulated as ointment product. The formulations were characterized by determining the pharmaceutical characteristics like pH, skin irritancy test, viscosity, appearance, extrudability, spreadability, washability, and swelling index. No specific edema or erythema symptoms were seen following treatment for a continuous seven days according to the skin irritation test investigation. The formulations’ pH levels were determined to be 5.2 (F1) and 5.7 (F2). F1 displayed swelling of 1.29%, whereas F2 displayed swelling of 1.14%. The spreadability of the two ointment formulations (F1 and F2) was 6.9 g.cm/sec and 5.2 g.cm/sec. For F1 and F2, the extrudability of the formulations from the collapsible tubes was determined to be +++ and ++, respectively. The viscosity was determined to be 4550 cps (F1) and 5300 cps (F2) when examining the rheological features of the formulations. The formulations’ washability was determined to be +++ for Formulation-1 and ++ for Formulation-2. The uses of polyherbal formulations in conventional medicine were revealed by this discovery, which also revitalized the concepts of ethnopharmacology in relation to contemporary medicine.

Oral medication delivery system research has resulted in the development of new formulations and technology. Such studies demonstrate the importance of the oral route among patients. We’ve gone through all of the benefits and drawbacks of medicated chewing gum as a contemporary medication delivery system, including the history, benefits and drawbacks, production processes, composition variations, assessment tests, and samples of different medicated chewing gum kinds. The acceptance of medicated chewing gum has grown over time. Chewing gum’s advantages and therapeutic benefits encourage its development, as shown by the fact that new formulations including new pharmaceuticals have been generated in the past and will be found in the market by the formation of new medicated chewing gums. Medicated chewing gums have a broad range of potential uses that will be identified in the future. Chewing gums now have the same qualification criteria as pills. Patients’ compliance is improved by using medicated chewing gums as a delivery strategy in patient-centered research.

In this study, the antithrombotic activity [antiplatelet, activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) assays] of standardized Dolichos biflorus seed extract (DBSE) and standardized Pterocarpus marsupium bark extract (PMBE) was determined. The study investigated the anticoagulant activities in vitro by performing activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) assays. Antiplatelet aggregation activity of the extract was examined using adenosine diphosphate (ADP), collagen, and thrombin as agonists, and the inhibitions of factor Xa and thrombin were also investigated. Bleeding and clotting times in mice were used to determine its anticoagulant activities in vivo. This study is the first to show that DBSE and PMBE possess anticoagulant properties, most likely as a result of its capacity to block thrombin activity. DBSE and PMBE could be thrombin inhibitors with anticoagulant therapeutic properties. However, when compared to positive control medications like heparin, argatroban, and dabigatran etexilate, DBSE’s and PMBE’s anticoagulant action is lesser.