Stress at work with various physical, biological, chemical and socio-economic factors contribute to day to day increased incidence of diabetes mellitus. Ayurveda is a rich treasure of safe and traditional materia medica which provides a promising field of drug research. An indigenous drug may not be as potent in lowering the blood sugar level as insulin but it may possess many other qualities which may make it more useful for the holistic management of the disease. In present study, an Ayurvedic formulation i.e. Madhumehar Yoga was assessed in terms of blood sugar levels as well as symptomatic relief in Madhumeha. A clinical trial was conducted on 69 subjects in whom 61 subjects completed the study. In trial Metformin (group I) shows 34.57% reduction in FBS while 26.85% reduction was observed in Ayurvedic formulation (group II). Reduction in FBS was statistically highly significant (p<0.001) in both the groups and the intergroup difference was statistically insignificant (p>0.05). Urine sugar was reduced by 100% in metformin and 93% in Ayurvedic formulation which is statistically highly significant (p<0.001) in both the groups and the intergroup difference was statistically insignificant (p>0.05). Considerable improvement in blood sugar levels and all signs and symptoms was observed in both groups. The study revealed that both the therapies were significantly effective in the management of Madhumeha, Ayurvedic drugs showed better efficacy on subjective parameters but Metformin was somewhere superior in lowering down the blood sugar levels.

Gridhrasi (Sciatica) is a crippling ailment cause pain in the lower back that spreads to the hip, buttocks and leg along the route of sciatic nerve. It is a major health problem related to locomotor system. Many experi-ence symptoms of recurrence and function limitations. A clinical comparative study was done on manage-ment of Gridhrasi with Rasna Guggulu and Trayodashang Guggulu to evaluate its therapeutic efficacy. The study concludes that the Percentage (%) of improvement shows both the trial drugs have reduced the symptoms but it was more in Trayodashang Guggulu (40%) than Rasna Guggulu (20%).