The growing use of chemical pesticides haphazardly and their harmful influence on ecosystem and human health highlight the necessity for safe and sustainable organic production in our time. The article reviews a general overview of organic farming; the impact of organic farming on soil health and climate mitigation in comparison with conventional farming practice in Nepal. The article identifies the problems and possibilities of organic farming to resuscitate the pesticide-dominated conventional practice in Nepal. Organic farming now has been embedded in the natural agriculture policy in Nepal. Organic farming benefits in terms of environmental protection along with better living health. Various governmental and non-governmental bodies, farmers, and individuals are working to promote organic farming in Nepal. With the increase in awareness of health and environmental concerns, the adoption of organic agriculture and the demand for organic agricultural products is increasing. It holds a great prospect in countries like ours where an integrated crop-livestock system is still prevalent in many parts of the country. As a result, an organic farming system in Nepal must be thoroughly investigated and supported through proper regulations and tactics. It is urged to supplant pesticide-based conventional farming with organic farming that leads towards agricultural sustainability for the upcoming generation.