8Nucleophilic exchange of 5'-iodo-A -THC and sodium iodide-125 afforded 5'-i0do-l~~I-A THC with a maximum specific activity of 42Ci/mmole. Ci/mmole by iodide-125 displacement of the corresponding 5'-tosylate.A hapten 5'-carb0xy-~~C-A -THC, for use in conjunction with this radioligand, was synthesized from 5'-bromo-A -THC.
8The specific activity could be increased to at least 100 9 8
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