During the preparation of the manuscript, the urea infusion rate was incorrectly given. The correct sentence containing the infusion rate appears below.The rats were allowed to recover from the surgery for 5 days and then were either infused with isotonic PBS or urea (100 mg/kg/h) for 48 hours using a microdialysis pump.The JCI regrets the error.
Table 3Summary of original and new experiments with Substance P and intracellular calcium
Research on home-based interventions directed toward promoting positive interaction between mothers and their young children has become a less active field in spite of evidence that some programs sustain meaningful improvements in the lives of mothers and children. The purpose of this paper is to clarify some of the methodological problems of home-based intervention research and to suggest future directions. Several major projects are discussed to illustrate different perspectives, trade-offs, and promising strategies for dealing with key issues: (a) congruence between goals and methods, (b) sample selection and retention, and (c) measurement and design. The authors suggest that designing home-based interventions as longitudinal development research (rather than outcome evaluations) can provide valuable knowledge about ecological factors that affect the development of competence in parents and children and about effective ways to support families.
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