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Entropy of Cyclopentane 341 sum £(333/ ) + 2£(494/ ) + 2£(1058/ ), which fits the data over the entire experimental range of temperature. In both instances only the Debye function is of importance in the extrapolation of entropy. Table II Entropies at 298.16°K. (cal./dbg. mol.) MgaSiO* MgSiOs 0-50.12°K. (extrap.) 0.60 0.49

Keywords: Calopins / Lactones / Mushrooms / Natural products / Spiro compounds Boletus calopus and closely related mushrooms of the Boletus section Calopodes are characterized by their bitter taste, which is caused mainly by O-acetylcyclocalopin A (6a), a member of a series of unique δ-lactone derivatives. Besides the simple lactone calopin (1b) and its O-acetyl derivative 1a, the more complex cyclocalopins 6−12 have been isolated and their structures elucidated. Cyclocalopin D (10a) is an unpre-

The broad biological effects of isoquinolines prompted us to use them as chelating, nonleaving ligands in cis-platinum(II) antitumor complexes. The synthesis of several 1-(2-aminophenyl)isoquinoline derivatives with different levels of hydrogenation and varying substitution of the phenyl ring is reported. These compounds constitute a new class of ligands for the synthesis of oligocyclic platinum(II) complexes. In vitro cytotoxicity tests indicate that the most basic amine ligands afford the most effective complexes. Two of the new complexes were more potent against L1210 murine leukemia cells than the well-established antitumor compound cisplatinum.

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