Neurodegenerative disorders like Alzheimer’s are associated by plague formation of protein aggregates called amyloid proteins. Many natural-based products such as flavonoids, phenolic acids, iso-flavones, and polyunsaturated fatty acids play major role in therapeutic ability to degrade, slow down, and recondition the amyloid protein (amyloid protein inhibitors). These compounds extracted from plants have shown consequential potential in in vitro studies as well as in vivo studies. For requisite for brain nutritive growth, omega 3 fatty acids are important, whereas ß-carotene plays indispensable role in cognitive impairment and oxidative stress in the brain. It is described that omega 3 fatty acids are extracted from the source (flaxseed) by oil press method and ß-carotene is synthesized by physiochemical process from carrot. The main objective of this particular research topic is to provide more effectiveness in detaining the growth of amyloid protein inhibitors in brain. It is observed that the product with omega 3 and ß-carotene slow down the protein aggregation more efficiently than omega 3 capsules alone and intra-cerebroventricular injected streptozotocin. This can be determined by in silico activity of acetylcholinesterase. The analyses show extensive reciprocity between inhibitors and amyloid proteins. The administration of omega 3 with ß-carotene depreciates the amyloid protein aggregates more efficiently. Hence, it is suggested that the product can be used as treatment for neurodegenerative diseases like Alzheimer’s.

Plants are the natural wealth of any nation. India is a country rich in medicinal plants. Most of the herbal medicines are the only available therapy for certain diseases; for which there are no alternative synthetic therapies are available, eg; chloroquinine for malaria, digoxin for CHF etc. The side effects of medicinal plants are less compared to synthetic medicines. The plant Strychnos colubrina Linn was widely used by the tribes for the treatment of many diseases like inflammations, chicken pox, tumor etc. The dried powdered plant parts were subjected to successive extractions using, pet. ether, chloroform, methanol and water. The extracts of the plant S.colubrina Linn was subjected to preliminary qualitative and quantitative analysis. Then based on the GC – MS analysis, the chloroform extract was subjected to isolation. Three compounds were identified (two isoflavone: daidzein and 5, 7-dihydroxy- 3- ( 3- hydroxy-4- 3,4,5 trihydroxy-6-(hydroxymethyl) tetrahydro pyran-2-yloxy) phenyl) chromen-4-one) and a phenolic compound (isovanillic acid) The extract was subjected to in vitro anti – inflammatory screening and the isolated compounds were subjected to in vivo anti-inflammatory screening. All the three compounds were showed significant anti – inflammatory activity.