This experiment was conducted to find out the effects of Trichoderma viride on growth and yield of wheat at Institute of Agriculture and Animal Science, Lamjung Campus, Sundarbazar, Lamjung during December 2016 -April 2017. The experiment consisted of seven treatments; (T1: Control; T2: Soil + NPK; T3: Soil inoculated Trichoderma; T4: Trichoderma + FYM; T5: Trichoderma + ½ NPK; T6: Trichoderma + NPK and T7 = Trichoderma + NPK + FYM) laid out in completely randomized design (CRD) with three replications. The results showed that Trichoderma viride increased the plant height (4.6%), root weight (1.5%), leaf length (0.3%), panicle weight (9.1%), number of grains (3.8%), grain yield (36.5%), biological yield (13.7%), and biomass yield (2.7%) over control; while root length (-17.4%), number of leaves (-8.4%), tiller number (-10.8%), panicle number (-6.7%), panicle length (-8.4%) highlighted the negative impact of T. viride on wheat plant. T. viride displayed antagonism with inorganic fertilizer. When T. viride and NPK were accompanied with farmyard manure, most of the growth and yield parameter showed the highest value. Though Trichoderma viride decreases several growth parameters, it still can be used as biofertilizer which increases the grain yield. Using T. viride with a full dose of NPK during sowing stage may not be efficient and economical in terms of productivity. Introducing farmyard manure to T. viride gives better yield than T. viride alone.