Chronic hepatitis B (CHB) is a lifelong disease that harms human health. Bad lifestyle can induce and aggravate liver dysfunction of patients with CHB and even cause liver cirrhosis and liver cancer. Therefore, it is very important to help patients with CHB establish a good lifestyle to control their liver function deterioration. In this study, the theory of behavior change was applied to the nursing process of patients with CHB. The results showed that this method could help to improve liver function of patients with CHB, improve patients’ compliance behavior, and promote the development of self-management behavior ability and then improve patient satisfaction, which was worthy of promotion.