The aim of the study was to develop recommendations for the most effective and safe use of automated information systems in the investigation of criminal offences. The study involved the following methods: anamnestic method; descriptive analysis; forecasting method. The society uses an automated information system, which is defined as an ordered complex (system) of actions designed to implement a specific information technology for the performance of specified functions, which involves personnel and a complex of automation tools. They help to create databases, which are used in the investigation of criminal offences. The following measures are proposed for increasing the efficiency and expanding the scope of automated information systems in the investigation of crimes: ensure the protection of databases from external intrusions (cyber-attacks); ensure the internal security of the data contained in the respective databases in order to prevent privacy violations; ensure the organization of specialized training for law enforcement officers; automate a number of tactical operations using information systems; develop and adapt all possible information resources and technologies for the set procedural tasks; create unified databases of forensic data at the international and national levels. This study opens up prospects for further research for the most effective protection of databases from illegal use, which will contribute to the development of this direction in international and national criminal justice.