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Cardiovascular diseases (CVDs) are among the most impactful illnesses globally. Currently, the available therapeutic option has several side effects, including hypotension, bradycardia, arrhythmia, and alteration in different ion concentrations. Recently, bioactive compounds from natural sources, including plants, microorganisms, and marine creatures, have gained a lot of interest. Marine sources serve as reservoirs for new bioactive metabolites with various pharmacological activities. The marine-derived compound such as omega-3 acid ethyl esters, xyloketal B, asperlin, and saringosterol showed promising results in several CVDs. The present review focuses on marine-derived compounds’ cardioprotective potential for hypertension, ischemic heart disease, myocardial infarction, and atherosclerosis. In addition to therapeutic alternatives, the current use of marine-derived components, the future trajectory, and restrictions are also reviewed.

Background: Asthma is a chronic airway inflammatory disease, in which the excessive mucus adheres to the airway tube and causes narrowing of the respiration tube which is responsible for the difficulty in breathing. Around 235 million persons are affected with severe asthma worldwide. Purpose: The purpose of this study is to investigate and review the mechanisms of treatment strategies for asthma and the benefits or complications of nutrition supplements used in asthma, and the role of international agencies which stands for the treatment and management of asthma. Method: We search the randomized clinical trial, case reports, clinical studies, and preclinical studies with the use of search keys like asthma exacerbation, treatment strategies involve in asthma, Preclinical studies of asthma, supplement support or management of asthma, etc. we search the total 311 studies and based upon the inclusion criteria total 123 studies are included. Conclusion: According to the findings corticosteroids and Leukotrienes are mainly used for the treatment of early stages of asthma, for severe inflammation, the add-on therapy for corticosteroids with SABA and LABA may effective. Some biological compounds like Omalizumab, Reslizumab, and Benralizumab are used to treat asthma.

Tylophora indica (Burm f.) Merill. (Family: Asclepidaceae) generally popular as Antmul is a twining perennial plant seen in southern and eastern region of India in planes, forests and hilly areas. This is seen growing in many states in India like Bengal, Uttar Pradesh, Assam, Orissa (Wealth of India, 1969-1972). The plant is a climber or shrub with branches and is observed growing up to height of 1.5 meters, Leaves shape are ovateoblong to elliptic-oblong with 3-10 cm length and 1.5-7 cm width (Kirtikar and Basu, 1991). Plant roots are long fleshy and fissured along the length and are with light brown, corky bark. The plant has little size flowers and are 1-1.5 cm across, in 2-3 flowers fascicles (bundle) in axillary umbellate cymes. Calyx has divisions almost to the base, looks massively hairy from outside; segments laneolate, acute. Corolla is green to yellow or geen to purple, lobes oblong and acute. Fruit a follicle, up to 7 X 1 cm, ovoid lanceolate, tapering at top forming fine mucro, finally striate, glabrous, seeds 0.6-0.8 X 0.3-0.4 cm long. The plant is originated from India. The plant can be found at an elevation of 1260 m in the sub Himalayan tract, central, peninsular India. It is seen in Eastern, North-ast and Bengal and parts of South India. Tylophora indica is a perennial plant with long thick roots branching climber .The plant is observed growing in planes and hilly land in India upto an altitude of 1000 meter in various states like Assam, Bengal, Orissa (Gupta, 2003). Phytochemistry The plant contain various active ingredients like tylophorine,tylophorinine, tylophorinidine and in plant body,leaves roots (Mohammad, 2008) Roots and leaves of plant also contain septidine too. The plant body also contain alkaloids were reported desmethyltylophorine, methyltylophorinindine, isotylocrebrine, skimmianine, gamafagarine. The compounds which are non alkaloidal and isolated are quercetin, kaempferol, octacosanoate, sigmasterol, betasitosterol, tyloindane, cetylalcohol, wax, resin, coutchone, pigments, tannins, glucose, calcium salts, potassium chloride (Gupta et al., 2010).

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