Substituted guanidines were synthesized by the guanylation of amines with carbodiimides using Zn-Al hydrotalcite (Zn-Al HT) catalyst. Zn-Al HT was prepared by co-precipitation method and characterized by X-ray powder diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Raman and Thermogravimetric-Differential Thermal Analysis (TG-DTA). The heterogeneous catalyst afforded moderate to good yields (∼50-60 %) of substituted guanidines in toluene at 110 • C in 12 h. The catalyst was recovered quantitatively by simple filtration and reused for three cycles with consistent activity. The XRD and FTIR studies of the used catalyst shows no variation in the structure of the catalyst even after three recycles.

Synthesis of Substituted Guanidines Using Zn-Al Hydrotalcite Catalyst. -The Zn-Al hydrotalcite catalyst can be easily recovered by simple filtration and reused for three cycles without significant loss of its activity. -(LAKSHMI KANTAM*, M.; DUPATI, V.; VALLABHA, S. J.; MANORAMA, S. V.; J. Chem. Sci. (Bangalore, India) 125 (2013) 6, 1339-1345, http://dx.