Silver and its compounds have been used for thousands of years as antibacterial and medicinal agents. Silver nanoparticles (AgNPs) subsequently received much attention due to their unusual physical, chemical, and biological properties, which are mainly caused by AgNP size, structure, composition, luster, and structure compared to their bulk species. When free radicals interact with bacteria, they can cause damage to the cell membrane, enabling it to penetrate and eventually lead to cell death. Compared to other salts, silver nanoparticles have excellent antibacterial activity due to their large surface area, allowing for high interaction with bacteria. There are many techniques for producing silver nanoparticles, including physical, chemical, and biological processes.Physical and chemical processes for making silver nanoparticles are expensive and complicated, whereas biological approaches are easier and safer to implement. In the biological and environmental areas, metal nanoparticles with controlled particle size and surface chemistry have a broad spectrum of applications. Nanomaterials must becharacterized in addition to the manufacturing procedures to explore differences in activity based on morphological distinctions. AgNPs are widely used as antibacterial agents in the field of health, food storage, textiles, and various environmental applications.So, in this systematic review, we examined silver nanoparticle preparation methods, characterization, applications, and fundamental concepts of silver nanoparticles (AgNPs).

Rheumatoid arthritis is a chronic inflammatory illness characterized by joint stiffness, bone and cartilage destruction, and swelling above the joints. The condition is linked to chemicals found within the major histocompatibility complex, also as T-cells that are hooked in to them. The condition is more severe in women than in men, also as within the elderly population. The effects of gender on the clinical course of the disease are studied, but the results are mixed. The factor like genetic, environmental, smoking, and age of a person were trigger’s the rheumatoid arthritis. The other clinical complications were observed in patients with rheumatoid arthritis which includes depression, infection, malignancy, cardiovascular disorder, pulmonary disease etc. According to research, RA risk might be impacted by a genetic predisposition, environmental factors, or a combination of both. Immune cells such as lymphocytes, neutrophils, and macrophages have long been thought to have a role in the development of RA involved in pathological mechanism. Rheumatoid arthritis have been diagnosed by imaging with colour doppler sonography or gadolinium-enhanced magnetic resonance imaging can detect the presence of osynovitis, and serologic testing for auto-antibodies and APRs was required to diagnose rheumatoid arthritis. To cure and prevent the patients form rheumatoid arthritis it is very necessary to take suitable treatment. So, in present work we also highlighted the available drugs used for the treatment of RA. The first line therapy agents include Non-steroidalantiinflammatory drugs, and corticosteroids. The second line agents used in RA are Disease modifying Antirheumatic drugs (DMARDs). The patients having age more than 60 years also need surgery to cure rheumatoid arthritis. To decrease the side effects from some potent agents include methotrexate the vitamin D, folic acid, and dietary supplements were used with treatment. So, this review article helps the researcher’s to understand the basic overview of rheumatoid arthritis, causes, other disease development, and management process with regards to available FDA approved therapeutics, and published patents.