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147 ganisms and without cross-resistance to the majority of other clinically useful an ti biotics. Oleandomycin is an agent which, with the exception of cross-resistance to members of the erythromycin group, displays these properties.Summary (1) In vitro under the specific conditions of the gradient plate technic, combinations of sulfisoxazole and oleandomycin in specific ratios show an activity superior to that observed with the single constituents.( 2 ) Supplemental activity was also observed in vivo in the streptococcal, staphylococcal and pneumococcal infections when the ratio of the combination of sulfisoxazole to oleandomycin was 5 to 1. ( 3 ) The same type of effect was also observed in Salmonella schottmuelleri infection of mice when activity of sulfisoxazole was determined in a constant, inactive amount of oleandomycin.The authors wish to express their gratitude to Miss A. Bagnole, Miss J. Giamportone and Miss J. Tinsley who cooperated in carrying out the experiments.

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