An epidemiological study was executed to determine the prevalence of common diseases in camels of Cholistan desert, Pakistan. Starting from Fort Abbas to Rahim Yar Khan, the survey was carried out from May 2010 to April 2011. Epidemiological data was collected from the camel herds of Cholistan (Locally called as Tobbas) and analyzed to interpret current scenario of camel diseases. The overall prevalence of all diseases in camels was 15.8%. The prevalence of trypanosomiasis, pneumonia, mange, and anthrax in camels was recorded as 5.39%, 5.49%, 3.14% and 1.80%, respectively. Considering this baseline information, strategic disease control measures should be develop to combat infectious, parasitic and miscellaneous diseases especially Surra, pneumonia, mange and anthrax. All copyrights reserved to Nexus® academic publishers