Objective: Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy and methotrexate (MTX) as a first-line therapy. Vitamin A helps to increase trophoblast cell regression, as well as to decrease β-hCG levels. Vitamin A also increases the effectiveness of MTX by inducing more malignant cell death than MTX alone. Therefore, the aim of the current study was to analyze the changes in β-hCG levels in low-risk GTN patients following vitamin A administration. Methods: This study was a randomized clinical trial, which examined initial serum vitamin A and β-hCG levels in GTN patients before and after three cycles of MTX therapy. Patients were given vitamin A supplementation of 6,000 IU (1.8 mg RAEs) per day, and the changes in serum β-hCG were observed after three cycles. Patients were grouped by β-hCG levels (decreased or stagnant). Results: A total of 32 low-risks GTN patients were divided into the intervention group (16 patients who received vitamin A supplementation) and the control group (16 patients who did not receive vitamin A supplementation). In the intervention group, the average initial β-hCG level was 170,949.3 ± 354,452.1 mIU/mL, and the average β-hCG post-cycle level was 1,611.9 ± 3,652.5 mIU/mL. In the control group, the average initial β-hCG level was 178,834.1 ± 2913844.6 mIU/mL, and the average β-hCG post-cycle level was 25,388.5 ± 58,437.7 mIU/mL. Conclusion: In patients with low-risk GTN who underwent MTX chemotherapy, the levels of β-hCG and the incidence of chemo resistance in the intervention group were lower than those in the control group. Older age may also influence the incidence of chemo resistance in GTN patients. Oral administration of 6,000 IU vitamin A could help to reduce β-hCG levels in low-risk GTN patients who receive MTX chemotherapy.

Obesitas merupakan masalah epidemik. Setiap tahunnya terjadi peningkatan persentase individu dengan IMT tinggi (overweight atau obese). Beberapa penyakit tidak menular seperti hipertensi, penyakit jantung koroner (PJK) dan stroke mempunyai faktor risiko yang sama yaitu meningkatnya indeks massa tubuh dan meningkatnya konsentrasi profil lipid. Penelitian ini bertujuan untuk mengetahui korelasi antara indeks massa tubuh dengan konsentrasi profil lipid. Penelitian ini menggunakan data sekunder pendekatan studi potong lintang (cross sectional). Jumlah sampel sebanyak 99 orang. Analisis data menggunakan uji korelasi rank Spearman. Karakteristik sampel pada data yang didapatkan menunjukkan sebanyak 55% subjek termasuk dalam golongan yang mempunyai berat badan yang berlebih (overweight dan obese). Rerata Indeks Massa Tubuh dan profil lipid lebih tinggi pada perempuan bila dibandingkan dengan laki-laki, kecuali untuk kadar TG. Koefisien korelasi IMT dengan kolesterol total (rs = 0,244 p = 0,015), dengan HDL-C (rs=-0,222 p= 0,027), dengan LDL-C (rs = 0,223 p = 0,026), dan dengan TG (rs = 0,242 p = 0,016).Terdapat korelasi yang signifikan antara indeks massa tubuh dengan profil lipid.Kata Kunci: HDL-C, IMT, Kolesterol Total, LDL-C, TG

Background: The incidence of gestational trophoblastic neoplasia (GTN) is high in Indonesia. Based on the FIGO prognostic score, GTN is classified into low-risk and high-risk categories. The high-risk group requires multidrug chemotherapy whereas the low-risk group requires single-drug chemotherapy. Response to chemotherapy would reflect the remission rate. The aim of this study was to describe the response to chemotherapy in GTN patients Methods: This was a cross-sectional descriptive retrospective study on medical records of patients with GTN treated in Dr. Hasan Sadikin General Hospital during the period of 2016 to 2018. The inclusion criteria were GTN patients who received > 3 cycles of chemotherapy while the exclusion criteria were incomplete, inaccessible, or missing data. Data were collected on patient’s age, parity, history of previous pregnancy, pregnancy-therapy interval, tumor size, number and location of metastases, and history of failed chemotherapy. Results: Of the189 medical records of the GTN patient collected, only 88 met the inclusion criteria, (63.6% low risk and 36.4% high risk). Most patients were responsive to chemotherapy (61.4%), aged<40 years old, multiparity, tumor size >5 cm, had 4 month interval from previous pregnancy <4 months, had a history of molar pregnancy, had no metastases, and no previous failed chemotherapy. Conclusion: The chemotherapy response in gestational trophoblastic neoplasm patients is fairly good with most patients are in the low-risk groups. Specific tumor markers used in early diagnosis of GTN may play a major role.