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In vivo, CMP, which is a x-casein fragment, is the first hydrolysis product emptied from the stomach after milk or casein ingestion. Several [(1989) Am J Physiol256, G989-G996]. Fractions were infused into the lumen of the isolated intestine at physiological doses for 30 min. For every fraction 6 trials were performed.Venous effluent was collected as 2-min fractions for 30 min, and CCK8 was determined by RIA. NaCl perfusion was used as control.