The subunits of NF-cB, NFKB1 (formerly p5O) and RelA (formerly p65), belong to a growing family of transcription factors that share extensive similarity to the c-rel proto-oncogene product. The homology extends over a highly conserved stretch of approximately 300 amino acids termed the Rel homology domain (RHD).This region has been shown to be involved in both multimerization (homo-and heterodimerization)
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