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The measurements of cytoplasmic and lysosomal pH changes (pH and pH1 conespondently) caused by the interaction of tetrasuiphonated aluminum phthalocyanine (Pc) with cultured cells, were performed. The distinct decrease of pH (0.25±0.04 un.) and pH1 (0.54±0.08 un.) followed by the increase back to the initial values was observed during the first 60-80 minutes of the Pc accumulation. Irradiation with light of the Pc-loaded cells also caused the temporary pH decrease (0.22±0.02 un.).The dependence of cell mactivation efficiency on cytoplasmic pH was studied; showing that the degree of photodynamic damage is reduced at higher pH values.

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