No abstract

The lack of suitable radiolabeled agents for photoscanning adrenal medullary tumors prompted synthesis of 4-hydroxy-3-iodo-(2), 3-hydroxy-6-iodo-(3), and 3-hydroxy-5-iodophenylethylamine (4) radiolabeled with iodine-125. Radioiodination by isotope exchange was unsuccessful for 3 and 4, but the former was obtained by the direct radioiodination of m-tyramine hydrochloride. Tissue distribution studies in dogs with 2 and 3 revealed extensive in vivo deiodination and no selective localization in adrenal medulla or adrenergically innervated tissues.Despite the rapid advances in nuclear medicine in recent years, there is still no suitable radiopharmaceutical available to aid in the diagnosis of neural crest tumors such as pheochromocytoma and neuroblastoma.# These tumors are a group of functional tumors which arise from the sympathetic chain and adrenal medulla and are capable of producing large quantities of catecholamines and their metabolites.2

Auf der Suche nach Radiojod‐markierten"Verbindungen, die die Auffindung von Tumoren erleichtern, wurden die 335J‐markierten Tyramine (II), (VII) und (XVII) auf den im Formelschema angegebenen Wegen dargestellt.