The author analyzed the causes of death of 8082 coal miners who were diagnosed with occupational disease in Rostov Occupational pathology center and died between 1990 and 2015. A comparative analysis of the structure of miners’ causes of death and the structure of causes of death of adult male population of Rostov region for the same calendar period was carried out.

Complex study of work conditions and health state covered workers of electric locomotive construction plant. Occupational health disorders appeared to be highly reliably associated not only with traditional factors of work and working process, but also with psycho-social occupational factors. Findings were leading types of diseases in the workers, prediction of health risk from circulatory system diseases. Based on integrated approach to evaluation of work conditions, workers’ health care and well-being at workplace, the authors specified and scientifically justified a complex program of health disorders prevention for workers of major electric locomotive construction plant.

Retrospective analysis covered stages of formation and development of Occupational Pathology center in Rostov region, its structure and functional interrelations, information basis and scientific methodic supplies of its activities. The authors summarized materials on organization of diagnostic survey, treatment, prevention of occupational diseases in miners and workers of various economic branches, of medical rehabilitation of patients. The article covers development directions of system concerning workers’ health preservation in regional occupational pathology center.