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The mechanism of breakage in the turbulent flow in Kenics mixer has been investigated theoretically and experimentally. Drops trajectories (as a function of drop size and Re number) in the mixer were calculated using particle/drops tracking model and areas in the mixer where drops were exposed to the highest energy dissipation rate were identified. The calculated trajectories were experimentally verified in a glass Kenics mixer and the drop deformation/breakage was analyzed using high-speed video camera. The results indicate that even in turbulent flow, the mechanism of drop breakage depends on the Re number and position in the mixer.