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Tremor is the most common type of movement disorders. In practice this differential diagnosis of hyperkinesis is diagnosed clinically and the use of additional methods of objective assessment of tremor increases the accuracy of diagnosis. The use of paraclinical methods of objective assessment of tremor improves the accuracy of diagnosis. Comparison of the neurophysiological parameters of tremor with clinical characteristics has a high diagnostic value, which justifies its use in the routine practice of neurologists. The purpose of the review is to analysis basic electrophysiological characteristics of pathological tremor, as well as the presentation of the material of its own observation.

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The article provides a review of the pharmacokinetics of levodopa and personalized therapy for Parkinson’s disease. We analyzed the methods used to prolong the action of levodopa using peripheral inhibitors of DOPA decarboxylase, catechol-O-methyltransferase inhibitors, and monoamine oxidase type B inhibitors. The influence of levodopa metabolites with their own biological activity in the possible progression of the disease is emphasized. The role of determining the concentration of levodopa in blood plasma is discussed, as well as the concept of «continuous dopamine stimulation» for the prevention and treatment of side effects of long-term levodopa therapy, such as drug dyskinesias, motor and non-motor fluctuations. The article also provides an overview of the modern forms of levodopa that are currently being investigated.

Аннотация. Головные боли -одна из наиболее частых жалоб пациентов в неврологической практике. По данным эпидемиологических исследований, той или иной формой цефалгии страдают 79 % населения Европы, 75 % -в Латвии и 62 % -в России. Кроме того, головная боль является одной из распространенных причин нетрудоспособности, а затраты на лечение одного пациента в США достигают более ТАППАХОВ Алексей Алексеевич -канд. мед. наук, старший преподаватель кафедры внутренних болезней и общеврачебной практики (семейной медицины) ФПОВ, старший научный сотрудник учебно-научной лаборатории нейропсихофизиологических исследований Клиники Медицинского института ФГАОУ