The abnormal habituation could be explained by the periodic changes of physiological parameters during the pain-free interval. The impaired habituation of early CNV in migraine is associated with increased orienting activity seen only in the central component (AB) of OR.

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The effects of aspirin on the contingent negative variation (CNV) of 16 healthy, right-handed volunteers were studied in accordance with a placebo-controlled double-blind crossover design. Early and late CNV factors were measured. Aspirin caused a statistically significant decrease of the early wave and an increase of mean amplitude of the late wave. A central action of aspirin, affecting noradrenergic and dopaminergic structures, may be responsible for the CNV changes.

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