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OBJECTIVE: To investigate the clinical application of ultrasonic bone knife (UBK) combined with dental electric motor (DEM) in the extraction of mandibular middle and low impacted teeth. Methods: From January 2022 to May 2023,200 patients with wisdom teeth were randomly divided into three groups: experimental group A (UBK combined with DEM) and experimental group B (UBK combined with high-speed turbine mobile phone (HSTMP)), control group (bone chisel split crown (BCSC)). The operation time, psychological state during operation, pain, swelling, limitation of mouth opening and other complications on the first, second and third days after operation were recorded. Results: The operation time of experimental group A(EAG) (12.95 ± 2.12) minutes was shorter than that of experimental group B (EBG) (17.06 ± 2.25) minutes and control group (CG) (23.43 ± 2.18) minutes, the difference was statistically significant (P < 0.05). The psychological state of EAG was significantly lower than that of EBG and CG (P < 0.05). The postoperative pain, swelling, limitation of mouth opening and complications in the EAG were significantly lower than those in the EBG and CG (P < 0.05). CONCLUSION: UBK combined with DEM in the extraction of mandibular middle and low obstructed teeth has good results, good prognosis, high safety, short operation time, better psychological status of patients, low postoperative pain, swelling, mouth opening restriction and complication rate, and is currently the preferred extraction method.