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The energy spacing between the ground-state spin doublet of 4 Λ He(1 + ,0 + ) was determined to be 1406 ± 2 ± 2 keV, by measuring γ rays for the 1 + → 0 + transition with a high efficiency germanium detector array in coincidence with the 4 He(K − , π − ) 4Λ He reaction at J-PARC. In comparison to the corresponding energy spacing in the mirror hypernucleus 4 Λ H, the present result clearly indicates the existence of charge symmetry breaking (CSB) in ΛN interaction. It is also found that the CSB effect is large in the 0 + ground state but is by one order of magnitude smaller in the 1 + excited state, demonstrating that the ΛN CSB interaction has spin dependence.

The present status of hypernuclear γ-ray spectroscopy with Hyperball is summarized. We observed two γ transitions of 16 Λ O(1 − → 1 − , 0 − ) and obtained the strength of the ΛN tensor force. In 10 B(K − , π − γ) data, we did not observe the spin-flip M1 transition of 10 Λ B(2 − → 1 − ), but γ rays from hyperfragments such as 7 Λ Li(7/2 + → 5/2 + ) and 9 Λ Be(3/2 + → 1/2 + ) were observed. In 11 B(π + , K + γ) data, we observed six γ transitions of 11 Λ B. We also attempted an inclusive γ-ray measurement with stopped K − beam. † Present address:

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with immunomodulatory and anti-inflammatory effects. Beyond its direct effects, the metabolic products of EPA also regulate various immune responses. Animal experiments demonstrated that EPA reduces adipose inflammation in high fat diet-induced obese mouse. However, the effects of EPA on infiltrated immune cell populations in adipose tissue and underlying mechanisms remain to be elucidated. We performed flow cytometry of stromal vascular fraction of epididymal adipose tissues from C57BL/6J and ob/ob mice fed normal chow mixed with or without 5% EPA. The numbers of hematopoietic cells, including Tregs, were higher in both C57BL/6J and ob/ob mice fed EPA diet compared with control diet. EPA enhanced the induction of Tregs in co-cultures of adipose tissue macrophages (ATMs) and naïve T cells. Among EPA metabolites, 5-HEPE was the most potent inducer of Tregs. GPR119 and GPR120 are receptors for 5-HEPE and EPA, respectively, and antagonist of GPR119 blocked Treg induction by EPA in the presence of ATMs. Alox5 gene encodes 5-lipoxygenase enzyme catalyzing EPA into 5-HEPE, and inhibitor of 5-lipoxygenase down-regulated EPA-mediated induction of adipose tissue Tregs in ob/ob mice. The study findings demonstrated that both EPA and 5-HEPE enhance ATM-mediated Treg induction.