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\\\\ INTRODUCTION Trypanosoma evansi is a protozoa responsible for a disease called ' mechanically and cyclically biting flies (Desquesneset al., most widely spread trypanosome globally and is pathogenic to its host (Hoare, 1872). Furthermore, this parasite has the g widest range of host thus positioned within the spectrum of most important animal health problem in sub-Saharan Africa (T 2013). On clinical perspective, the disease manifests itself by weakness, fever, anasarca, ataxia, paralysis of the hindquarter and death (Yadev al., 2016). Despite T. evansi parasite of camel, there is likelihood that small ruminants herded together with camels especially Kano brown goats may become infected with the parasite and may serve as reservoir host for the agent. Kano brown goats contributes proportion of the goat's population in Nigeria ABSTRACT Trypanosomosis is a vector borne protozoan disease that is caused by varied members of the genus, Trypanosoma which affect different species of domestic and wild animals including humans. The disease processprovokes alterations in serum enzymes activities in the affected host. This study aimed at investigating the parasitological effects and changes in levels of some serum enzymes activities in Kano brown goats following e infection with T. evansi originally isolated from naturally infected camels at Maigatari. Infection was through the jugular veins of the experimental subjects (3 infected and2uninfected controls) at dose rate of 2.0 x 10 days. Sequel to the infection, infected goats developed clinical trypanosomosis and parasites were detected in the peripheral blood of all infected animals at varied prepatent period between 3 and 7 days post infection (DPI). First peak o at 9 DPI and second at 14 DPI and death was recorded on the 70 and 133 DPI respectively among the infected group. After 84 DPI, no parasite could be detected and control subjects remained aparasitaemic throughout the experiment aminotransferase (ALT) and aspartate aminotransferase (AST), there was significant (P < 0.05) elevation in the infected subjects. The study showedT. evansi isolate caused infection caused changes in the activities of s