The aim: Evaluation of the influence of plant protection chemicals on the fatty acid composition of sunflower seeds. Materials and methods: Study of the effects of pesticides, study of the effects of pesticides on the fatty acid composition (lipid) of sunflower seed by gas-liquid chromatography was studied. Results: It was found that the content of oleic and linoleic unsaturated fatty acids did not differ significantly from the control. The content of linolenic and arachidonic acids was at the level of the control group. A similar pattern was observed in relation to the content of saturated fatty acids, in particular myristic, pentodecanoic, palmitic, margaric, stearic. The total content of fatty acids (unsaturated fatty acids and saturated fatty) selected under different seed protection schemes did not differ significantly from control. Conclusions: It is proved that the application of the investigated pesticides in various schemes of chemical protection of sunflower crops does not affect the nutritional and biological value of the seeds.

The paper presents the features of the development of endothelial dysfunction in workers under lead exposure. The results of laboratory manifestations of endothelial dysfunction have been demonstrated on the base of the study of parameters of vascular molecule of adhesion vCaM-1, soluble molecule of intercellular adhesion Sіcam-1, endothelin-1 in the blood of workers who professionally contact with lead. The features of formation of endothelial dysfunction, depending on the content of lead in the blood were identified. The thresholds for the studied parameters of endothelial dysfunction which are associated with high risk of atherosclerosis in this category of workers were determined.

The calculated indices such as leukocytic (LI), hematological (HI) and nuclear (NI) became the most commonly used in clinical practice to determine the endogenous intoxication. The aim of this study was to determine informativeness of the calculation methods for verification of the endogenous intoxication in workers depending on the content of lead in their blood. The calculated indices (nuclear, hematological and leukocyte) have been carried out in the blood of 146 workers exposure to lead, whose concentration in the air of the working area exceeded the maximum permissible concentration 1.4–1.8 times (study group) and 57 workers in the control group to study the parameters of endotoxemia. The index of reaction of a systemic response, sensitization index, an index of ratio between neutrophils and lymphocytes (IRNL) and an index of ratio between lymphocytes and eosinophils (IRLE) have been carried out in the blood sample of all workers to indicate the state of antitoxic adaptogenic system. The increase in Pb-K accompanied by statistically significant increase in the calculated indices of endogenous intoxication were detected for workers exposed lead. The endogenous intoxication characterized by changes in the calculated index leukocytic (LI), hematological (HI) and nuclear (NI) has been detected in workers exposed lead.

The aim: Diagnosis of bronchopulmonary pathology in the intensive care unit in patients with obstetric and gynaecological diseases and to implement aspects of the BLUE protocol in an intensive care unit for pregnant women with lung diseases. Materials and methods: The study involved pregnant women admitted to the intensive care unit at the city centre for reproductive medicine. To study the bronchopulmonary system, an Aloka 3500 ultrasound scanner was used, a chest X-ray was performed, spirometry study of the function of external respiration. Results: Identified radiological changes in the lungs that were confirmed by ultrasound. Data on changes in external respiration indices showed the presence of respiratory failure by restrictive type and was not accompanied by a change in the gas composition of the blood (SpO2 and EtCO2). Conclusions: technique for ultrasound examination of the bronchi-pulmonary system in pregnant women was developed and introduced in the intensive care unit. Ultrasound profiles of lung diseases were identified, which allow determining the intra and extrapulmonary changes in pregnant women in the early stages of pathology.

The aim: To define an ability to use pig as biomodel for experimental and clinical studies in order to develop new approaches of treatment of the rectal pathology. Materials and methods: For the research two groups were used. I group includes 50 humans (27 females and 23 males), II group includes 8 vietnamese pot-bellied pigs. After magneresonance Imaging the 3D reconstruction of rectum was made. Results and conclusions: Topography, structure, age and gender peculiarities of pig`s and human`s rectum in comparative aspect are described in this article. With the help of modern methods, namely 3D reconstruction, the structure of the pig`s and human`s rectum was reconstructed. The morphological parameters, such as size of anorectal and rectosigmoid angles, the length of the rectum and its parts, were determinated. The 3D reconstruction demonstrated that size of anorectal and rectosigmoid angles, the length of the pig`s rectum are morphologicaly identical to the same parametres of human`s rectum. Thus, it is proved that pigs can be used as biomodels in experimental and clinical studies for development the new methods of treatment the rectal pathology in humans.