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In a hydrops model developed to be more comparable to the histopathologic appearance of Meniere's disease in the inner ear, no hydrostatic pressure difference was measured between the perilymphatic and endolymphatic spaces. The only functional difference from control ears we found was a decreased endocochlear potential.

Perilymphatic and endolymphatic pressures were measured consecutively in the normal guinea pig using a WPI 900A micropressure system. The mean (n = 10) perilymphatic and endolymphatic pressures were 2.26 and 2.31 cm H₂O, respectively. There was no statistically significant difference between the pressures of the endolymphatic and perilymphatic compartments. The measured values were within the range of pressures found in the literature.

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