Androgen Biosynthesis Inhibitors between 0(2) and H(l) and a H bond type linkage (albeit a strong one) between 0(3) and H(l).The very strong interactions of this arrangement are partially relieved in 2 ways. As in the KHMal, KHClMal, and maleic acid structures the internal angles of the ring system are strained considerably. The two angles 0(2)-C(l)-C(2) and 0(3)-C(4)-C(3) are not significantly different from each other and average 119°36' ± 42'. Similarly the angles C(l)-C(2)-C(3) and C(2)-C(3)-C(4) are insignificantly different and average 130°24' ± 24'. These angles are however significantly different from their unstrained counterparts of 121°18' and 121°3 0', respec-

Aus dem Pregnen‐20‐oxim (I) wird durch Beckmann‐Umlagerung das 3β‐Acetoxy‐6‐methyl‐17β‐acetamino‐A5‐androsten (II) und aus diesem werden über das Amin (III) die verschiedensten N‐Substitutionsprodukte, z.B. (IV), (V), (VI) und der entsprechenden A4‐3‐Ketone (VII) und AL4‐3‐Ketone erhalten.