Rapid urban growth causes the increase of impervious surface which was converted from vegetation land. This affects the rate of water penetration into soils, the rise of surface runoff, and the lowering of groundwater levels. The expansion of the impervious surface gives rise to a series of changes in the physical environment, affecting the quality of life of people due to a change in the thermal energy balance. Therefore, the purpose of this study is to analyse of changes of impervious surface area Ho Chi Minh City and Ba Ria - Vung Tau province which is the marine national economic hub in the period of 2009-2020 by using Landsat satellite image data. The main methods used are NDWI, PISI indices and ISODATA algorithm. The results show that the area of impervious surface area of Ho Chi Minh City is very high with 18.5% in 2009 and 35% increasing rate from 2009-2020. There are 75% districts in Ho Chi Minh city having over 50% impervious surface area. Ba Ria-Vung Tau has lower impervious surface area with 5.8% in 2009 but having the incredible increasing rate– over 100%.