Objective:To evaluate the effect of transcatheter renal denervation (TRD) on presence and severity of pathological structural changes of a brain assessed by MRI in resistant hypertensive patients.Design and method: Forty three resistant hypertensive patients aged between 30-80 years were included in the study. TRD was performed as bilateral endovascular radiofrequency ablation of neural pathways adjacent to renal artery. Detailed clinical investigation, 24-h ABPM and brain MRI were performed in all patients at baseline and 6 months after TRD. The study endpoints were changes in presence and severity of leucoaraiosis (LA), liquorodynamic disturbance, lacuna infarcts (LI), focal white matter lesions (FWML) and also of their integrating index graded 0-4 in accordance with a number of these phenomena simultaneously presented in a patient (index of structural hypertensive encephalopathy).