1 In sti tu te of Re sear ch in Scien ce and Me di ci ne, Sa lem, In dia 2 In sti tu te of Car dio lo gy, Ban glo re, In dia 3 De par tme nt of Bioc he mis try, Al Arab Me di cal Uni ver si ty, Ben gha zi, Li bya *Cor res pon di ng aut hor: dhas ta gir @ya hoo.ca Ab stra ctIn tro duc tion: Peop le wi th meta bo lic syndro me are about twi ce as li ke ly to de ve lop ce reb ro vas cu lar di sea se (CVD) and over four ti mes as li ke ly to de ve lop type 2 dia be tes com pa red to sub jec ts wit hout me ta bo lic syndro me. This cro ss-sec tio nal po pu la tion ba sed stu dy was un der ta ken to explore the pre va len ce of me ta bo lic syndro me in a lo cal po pu la tion in In dia. Ma te ria ls and met ho ds: The pre va len ce was as ses sed in a group of 1,568 pa tien ts re fer red to Hi gh Te ch Hos pi tal a lia ted to Vi naya ka Mis sio ns Uni ver si ty, Sa lem, In dia. We ha ve ana lyzed the ove ra ll pre va len ce of me ta bo lic syndro me, as we ll as the num ber of com po nen ts of the me ta bo lic syndro me pre se nt in the in di vi dua ls in this stu dy. For all sub jec ts fol lowi ng va riab les we re col lec ted: age, gen der, wai st cir cum fe ren ce, blood pressu re and fas ti ng cli ni cal che mis try pa ra me te rs. Blood pres su re was mo ni to red and mea su red in a sit ti ng po si tion by a mer cu ry sphygmo ma no me ter. Blood sam ples for HDL-cho les te rol, trig lyce ri de and fas ti ng glu co se we re col lec ted af ter 12h over nig ht fa st. Re sul ts: In our group 33.17% of ma les and 27.04% of fe ma les we re iden ti ed as ha vi ng the me ta bo lic syndro me. Wai st cir cum fe ren ce, dysli pi de mia and im pai red glu co se to le ran ce we re sig ni can tly mo re pre va le nt in our ma le sub jec ts than in fe ma les. Mul tip le lo gis tic reg res sion ana lysis showed that in crea si ng age (OR (95% CI) = 1.06 (1.040-1.070); P < 0.001) and ma le gen der (OR (95% CI) = 1.50 (1.190-1.890); P < 0.05) we re sig ni ca nt pre dic to rs of me ta bo lic syndro me in In dia. Con clu sion:The me ta bo lic syndro me is substan tial ly pre va le nt in In dia. Its pre va len ce in creases wi th age and is hig her in men than in wo men. A fur ther stu dy is requi red to un der sta nd the ro le and in te r-re la tion ship be tween so me mo re and le ss known fac to rs pos sib ly as so cia ted wi th the meta bo lic syndro me. Key wor ds: dysli pi dae mia; me ta bo lic syndro me; pre va len ce; glu co se in to le ran ce; wai st cir cum fe ren ce In tro duc tionMe ta bo lic syndro me (MS) al so known as syndrome X is cha rac te ri zed by hyper trig lyce ri dae mia and low con cen tra tion of hi gh den si ty li pop ro tein (HDL) cho les te rol (dysli pi de mia), ele va ted blood pres su re, im pai red glu co se to le ran ce and cen tral obe si ty (1). Peop le wi th MS are about twi ce as li kely to de ve lop ce reb ro vas cu lar di sea se (CVD) and over four ti mes as li ke ly to de ve lop type 2 diabe tes com pa red to sub jec ts wit hout me ta bo lic syndrome (2-4). It is we ll re cog ni zed that the ...

NAFLD is recognized as risk factor per se for Coronary Artery Disease (CAD). Subjects with fatty liver have an increased risk to develop CAD, and are accompanied by an increase in inflammatory markers, C-reactive protein and also proatherogenic factors. Studies evaluating endothelial function showed that subjects with Non alcoholic fatty liver disease (NAFLD) had decreased endothelium-dependent vasodilatation correlated with the severity of liver disease In these subjects a strong association was seen with high triglycerides, suggesting that hypertriglyceridemia might be a crucial link between hepatic steatosis, insulin resistance, and endothelial dysfunction.

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NAFLD is an emerging problem in Asia, with raising prevalence and strong impact on the health care system. More and more people will suffer from not only the liver impairment of NAFLD but also the associated metabolic diseases e.g. DM and hypertension. The incidence of DM, hypertension, coronary heart diseases (CHD) and stroke will increase together with the prevalence of NAFLD and the health service expenditure will rise in coming decades. However the prevalence of and the metabolic diseases associated with NAFLD are not well studied in Asian populations. The objective of this project is to systematically review the articles related to NAFLD.